Stereoselective reduction of unsaturated 1,4-diketones. A practical route to chiral 1,4-diols
Autor: | Teresa Loscertales, Jaume Vilarrasa, Ramon Berenguer, Jordi Garcia, Judith Manzanal, Jordi Bach |
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Rok vydání: | 1997 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 38:1091-1094 |
ISSN: | 0040-4039 |
Popis: | A new synthetic route to C 2 -symmetric chiral 1,4-diols based on the borane-mediated oxazaborolidine-catalysed reduction of 2-ene-1,4-diones ( 2 ), of 2-yne-1,4-diones ( 3 ), and/or of Co-complexed diketones 4 is described. Good to excellent enantio- and diastereoselectivities have been obtained in the reduction of diketones 3 and 4 , catalysed by oxazaborolidines 6 and 5 , respectively. |
Databáze: | OpenAIRE |
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