Stereoselective reduction of unsaturated 1,4-diketones. A practical route to chiral 1,4-diols

Autor: Teresa Loscertales, Jaume Vilarrasa, Ramon Berenguer, Jordi Garcia, Judith Manzanal, Jordi Bach
Rok vydání: 1997
Předmět:
Zdroj: Tetrahedron Letters. 38:1091-1094
ISSN: 0040-4039
Popis: A new synthetic route to C 2 -symmetric chiral 1,4-diols based on the borane-mediated oxazaborolidine-catalysed reduction of 2-ene-1,4-diones ( 2 ), of 2-yne-1,4-diones ( 3 ), and/or of Co-complexed diketones 4 is described. Good to excellent enantio- and diastereoselectivities have been obtained in the reduction of diketones 3 and 4 , catalysed by oxazaborolidines 6 and 5 , respectively.
Databáze: OpenAIRE