ChemInform Abstract: Speciation Control During Suzuki-Miyaura Cross-Coupling of Haloaryl and Haloalkenyl MIDA Boronic Esters

Autor:	Ciaran P. Seath, Joanna M. Redmond, James W. B. Fyfe, Anderson Niall Andrew, Elena Valverde, Allan J. B. Watson, Alan R. Kennedy
Rok vydání:	2015
Předmět:	inorganic chemicals chemistry.chemical_compound Speciation chemistry Pinacol media_common.quotation_subject General Medicine Solubility Combinatorial chemistry Boronic acid Adduct media_common
Zdroj:	ChemInform. 46
ISSN:	0931-7597
Popis:	Boronic acid solution speciation can be controlled during the Suzuki-Miyaura cross-coupling of haloaryl N-methyliminodiacetic acid (MIDA) boronic esters to enable the formal homologation of boronic acid derivatives. The reaction is contingent upon control of the basic biphase and is thermodynamically driven: temperature control provides highly chemoselective access to either BMIDA adducts at room temperature or boronic acid pinacol ester (BPin) products at elevated temperature. Control experiments and solubility analyses have provided some insight into the mechanistic operation of the formal homologation process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31bc6b636d40bcb9f25d2b680121013e https://doi.org/10.1002/chin.201543192 Zobrazit plný text záznamu Plný text