ChemInform Abstract: Novel GRP78 Molecular Chaperone Expression Down-Regulators JBIR-04 and -05 Isolated from Streptomyces violaceoniger

Autor:	Miho Izumikawa, Shuhei Chijiwa, Motoki Takagi, Jun-ya Ueda, Kazuo Shin-ya
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Biochemistry Streptomyces violaceoniger chemistry medicine HT1080 General Medicine Fibrosarcoma medicine.disease Amino acid
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200814226
Popis:	In the course of our screening program for regulators of the expression of GRP78 molecular chaperone, JBIR-04 (1) and -05 (2) were isolated from Streptomyces violaceoniger 4541-SVS3 as congeners of prunustatin A (3). The structures of 1 and 2 were determined by the analyses of the spectroscopic data. These compounds mainly consist of an amino acid and amino acid derived α-hydroxy acid residues. 1 and 2 inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells, but their activities were highly reduced compared with those of 3 and SW-163A.
Databáze:	OpenAIRE
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