Synthesis of support-bound peptides carrying color labels

Autor:	Ferenc Major, Eugen Câmpian, Árpád Furka, Ferenc Sebestyén
Rok vydání:	1994
Předmět:	Acylation chemistry.chemical_classification chemistry.chemical_compound Blue dye Solid-phase synthesis chemistry Colored Drug Discovery Peptide synthesis Peptide Peptide library Combinatorial chemistry Sequence determination
Zdroj:	Drug Development Research. 33:98-101
ISSN:	0272-4391
DOI:	10.1002/ddr.430330206
Popis:	In order to check the possibility of labeling sub-libraries, we synthesized a colored support by acylation of aminomethyl resin with a special Boc-amino acid (a red azo dye). Syntheses of model peptides proved that the colored resin is suitable for solid phase peptide synthesis. Color labeling was also made by coupling resin-bound peptides at their N-termini with a blue dye. Colored resins as well as labeling at the N-terminus offer a possibility to simplify the preparation of support-bound peptide sub-library kits and their use in sequence determination of bioactive peptides. © 1994 Wiley-Less, Inc.
Databáze:	OpenAIRE
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