Manganese porphyrin-incorporated conjugated polymer nanoparticles for T1-enhanced magnetic resonance and fluorescent imaging
| Autor: | Shujuan Liu, Qiang Zhao, Tianshe Yang, Jiayang Jiang, Huanjie Wei, Zhuang Lv, Changyong Hu, Wenguo Feng |
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| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Nanoparticle Nanotechnology 02 engineering and technology Polymer Conjugated system 010402 general chemistry 021001 nanoscience & nanotechnology Photochemistry 01 natural sciences Fluorescence Porphyrin Conjugated Polyelectrolytes 0104 chemical sciences Inorganic Chemistry chemistry.chemical_compound chemistry Amphiphile Materials Chemistry Side chain Physical and Theoretical Chemistry 0210 nano-technology |
| Zdroj: | Inorganica Chimica Acta. 466:604-611 |
| ISSN: | 0020-1693 |
| Popis: | Conjugated polymer nanoparticles (CPNs) possess many useful and fascinating properties, including high brightness, excellent photostability, good water-dispersibility, low cytotoxicity, and easy functionalization, showing promising application in bioimaging. In this work, one kind of optical/magnetic conjugated polyelectrolyte has been designed and synthesized by introducing Mn(III) porphyrin (T1-weighted relaxivity) into a fluorescent fluorene based polymer backbone. Fluorescent/magnetic conjugated polymer nanoparticles (FM-CPNs) were prepared by self-assembly in the phosphate buffer solution caused by their amphiphilic structures with hydrophobic backbones and hydrophilic side chains. Their photophysical properties have been investigated in details via UV–vis absorption and fluorescent emission spectra. Investigation of its magnetic properties has shown that the FM-CPNs exhibit high T1-weighted relaxivity value, making them promising candidates for T1-enhanced magnetic resonance imaging agent. Further cell imaging has been realized successfully using FM-CPNs as staining label, and cytotoxicity was evaluated by the methyl thiazolyl tetrazolium (MTT) assay. |
| Databáze: | OpenAIRE |
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