| Popis: |
2-Ethyl-1,3-hexanediol (EHD; CAS No. 94-96-2) is an insect repellent and industrial chemical with skin as a major route of exposure. Groups of 25 timed-pregnant CD rats received cutaneous applications of undiluted EHD at dosages of 1.0, 2.0 and 4.0 ml/kg/day for 6 hr/day under occlusion on gestational days 6-15 inclusive. A. similar-sized control group received 4.0 ml/kg/day of deionized water with the same exposure regimein. Maternal toxicity was present at 4.0 ml/kg/day (reduced body weight gains and mild skin irritation that were not statistically significant, and increased liver weight that was statistically significant), and also minimally at 1.0 and 2.0 ml/kg/day (mild skin irritation and slightly increased but statistically significant relative liver weight to body weight ratio). At 4.0 ml/kg/day there was one visceral malformiation (unilateral hydroureter), increased incidences of three visceral variants (atelectasis, dilated lateral cerebral ventricle, and bilateral dilated ureter), and 1... |
