Asymmetric total synthesis and antidepressant activity of (−)-sila-mesembranol bearing a silicon stereocenter

Autor:	Zhenlei Song, Lingmin Chen, Gan Luo, Yi Li, Yu Fan, Lu Gao, Ruotian Jiang, Duyang Wang, Yufan Yang
Rok vydání:	2021
Předmět:	chemistry.chemical_compound chemistry Silicon Stereochemistry Yield (chemistry) Alkaloid Organic Chemistry Mesembranol chemistry.chemical_element Total synthesis Ring (chemistry) Carbon Stereocenter
Zdroj:	Organic Chemistry Frontiers. 8:5941-5947
ISSN:	2052-4129
DOI:	10.1039/d1qo00682g
Popis:	Asymmetric total synthesis of (−)-sila-mesembranol, the silicon analog of the natural alkaloid (−)-mesembranol has been achieved in 3.3% yield over 11 steps. The chiral silicon center was enantioselectively constructed via the asymmetric expansion of a silacyclobutane ring. The synthetic (−)-sila-mesembranol in mice exhibits better antidepressant effects than its carbon counterpart.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31a1c9f745a2f9fd51e91c726b2d058f https://doi.org/10.1039/d1qo00682g Zobrazit plný text záznamu