Extractos dializados de leucocitos para el tratamiento de infecciones recurrentes y severas en pacientes pediátricos con inmunodeficiencia celular: 15 años de experiencia
| Autor: | Gerardo C. Palacios, Lydia G. Rivera-Morales, María del Carmen Ayala, Nancy María González, Cristina Rodríguez-Padilla |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Leukocyte migration Gastrointestinal tract business.industry Urinary system Antimicrobial Gastroenterology 03 medical and health sciences 0302 clinical medicine Immune system medicine.anatomical_structure 030220 oncology & carcinogenesis Internal medicine Immunology and Allergy Medicine 030212 general & internal medicine Respiratory system business Adverse effect Respiratory tract |
| Zdroj: | Revista Alergia México. 66:27-37 |
| ISSN: | 2448-9190 0002-5151 |
| DOI: | 10.29262/ram.v66i1.531 |
| Popis: | Background: Dialyzable leukocyte extracts (DLE) have been used to treat several cellular immunodeficiency. Objective: To review the experience of a tertiary hospital in the use of DLE for the treatment of recurrent or severe infections in children with acquired cellular immunodeficiency not due to HIV. Methods: We reviewed the medical records of all children who received treatment with EDL of human or bovine origin between 1986 and 2000 to detect recurrent or severe infections without response to a specific antimicrobial therapy and with a quantitative or qualitative deficit in the cellular immune response. The dose of DLE was adjusted according to the percentage of T lymphocytes; the evolution of the patient was evaluated retrospectively for 5 years, the immune response was evaluated by subpopulation of lymphocytes and intradermal tests and inhibition of the leukocyte migration assay (LIF) to PPD, coccidioidin, varidase and candidin. Results: 150 children received DLE, age 7.0 ± 5.9 years. The most frequent indications included upper respiratory tract (71%), lower respiratory tract (43%), gastrointestinal tract (15%), urinary tract (15%) and neurological infections (4%) and coccidioidomycosis (3%). After starting the DLE, the numbers of T lymphocytes, LIF to PPD and varidase (> 20%) and the intradermal induration of the test increased (p |
| Databáze: | OpenAIRE |
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