BIOCHEMICAL AND MORPHOLOGICAL MARKERS OF EXPERIMENTAL SCOPOLAMINE-INDUCED NEURODEGENERATION AND THE EFFECT OF ENALAPRIL ON THEM
| Autor: | N. D. Filipets, Olga G. Kmet, Yurii M. Vepriuk, Taras I. Kmet, K. V. Vlasova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Antioxidant
Hydrochloride business.industry medicine.medical_treatment Neurodegeneration Hippocampus General Medicine Pharmacology medicine.disease Lesion chemistry.chemical_compound medicine.anatomical_structure chemistry Cerebral cortex medicine Neuron Enalapril medicine.symptom business medicine.drug |
| Zdroj: | Wiadomości Lekarskie. 73:2114-2119 |
| ISSN: | 0043-5147 |
| DOI: | 10.36740/wlek202010102 |
| Popis: | OBJECTIVE The aim: Was to study enalapril effect on protein peroxide oxidation and lipids of the cerebral cortex and hippocampus of rats with neurodegeneration pattern. PATIENTS AND METHODS Materials and methods: The experiments were conducted on nonlinear albino male rats 0,18-0,20 kg of the body weight. Modeled neurodegeneration was simulated by intraperitoneal introduction of scopolamine hydrochloride during 27 days in the dose of 1 mg/kg. Enalapril was introduced intraperitoneal in the dose of 1 mg/kg. RESULTS Results: In rats with modeled scopolamine-induced neurodegeneration in the cerebral cortex and hippocampus under enalapril effect, the content of products, reacting with 2-thiobarbituric acid and proteins of a neutral and major character, decreases, which is indicative of a reduced intensity of lipid and protein peroxide oxidation. Morphologic the number of cells with karyopyknosis signs decreases and a relative staining density of the neuron tigroid substance increases, which is indicative of inhibition of the progress of the cerebral neurodestructive processes under conditions of scopolamine-induced damage. CONCLUSION Conclusions: The obtained results are indicative of enalapril ability to improve the examined indices, which is the evidence of increased processes of antioxidant protection and possibility to inhibit neurodegeneration development in case of scopolamine induced lesion of the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|