| Popis: |
Equipment was developed to study the quantum yield for nitrofurazone in aqueous solutions. Various factors including the wavelength of irradiation, the pH of the medium, the presence of surfactants, polyethylene glycols or ultraviolet light absorbers influenced the photolability of the drug. The quantum yield decreased with increasing wavelength of incident radiation or pH of the medium. However, the quantum yield in surfactants was markedly higher than that in either polyethylene glycol or aqueous solution. The enhanced photodecomposition of drug in polyethylene glycol and surfactant solutions as compared to simple aqueous solution, is likely to be caused by the association of nitrofurazone with the surfactants and polyethylene glycol in the dark (ground state). There is a linear relationship between the molar uptake and quantum yield. The increase of quantum yield in the presence of ultraviolet light absorbers suggests that the compounds were acting as photosensitizers. |
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