Resistance High-Intensity Interval Training (HIIT) Improves Acute Gluconeogenesis from Lactate in Mice
| Autor: | André Henrique Ernandes de Amo, Maria Montserrat Diaz Pedrosa, Giselle Cristina Bueno, Isabela Ramos Mariano, Karen Saar Vedovelli, Julia Pedrosa Furlan, Gabrielle Yasmin Muller |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Liver perfusion business.industry Pharmaceutical Science Interval training Incremental exercise Lactate clearance Endocrinology Complementary and alternative medicine Gluconeogenesis Anaerobic glycolysis Internal medicine medicine Pharmacology (medical) business High-intensity interval training Perfusion |
| Zdroj: | American Journal of Sports Science. 7:53 |
| ISSN: | 2330-8559 |
| DOI: | 10.11648/j.ajss.20190702.12 |
| Popis: | High-intensity interval training (HIIT) markedly activates muscle anaerobic glycolysis and increases blood lactate. As the liver is a major organ for lactate clearance from the bloodstream, it might improve gluconeogenesis from lactate (NEO-lac) after a period of resistance HIIT. NEO-lac was evaluated by in situ liver perfusion in mice subjected to a resistance HIIT for 4 (T4) or 8 (T8) weeks, or not trained (T0). Perfusion was carried out immediately after an incremental exercise session to test the acute NEO-lac. Muscle strength (expressed as relative maximum load) and blood lactate were higher in T4 than in T0, but NEO-lac did not differ, possibly because of energy discharge of the liver and substrate overload. After 8 weeks of HIIT (T8), both muscle strength and liver NEO-lac increased, but blood lactate did not. The resistance HIIT for 8 weeks modulated liver gluconeogenic efficiency and capacity, which are important mechanisms for the improved clearance of blood lactate. |
| Databáze: | OpenAIRE |
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