The effect of link protein on the rheological properties of solutions of proteoglycan-hyaluronic acid aggregates
| Autor: | Go Matsumura, Mitsugu Tomioka |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Polymers and Plastics
biology Chemistry Intrinsic viscosity Cartilage Organic Chemistry Concentration effect Viscoelasticity Shear rate chemistry.chemical_compound Monomer medicine.anatomical_structure Proteoglycan Hyaluronic acid Materials Chemistry biology.protein medicine Biophysics Organic chemistry |
| Zdroj: | Carbohydrate Polymers. 27:197-203 |
| ISSN: | 0144-8617 |
| Popis: | Proteoglycan monomers, prepared from bovine nasal cartilage, were reassembled with a commercial hyaluronic acid, with or without link protein. The effects of link protein on the rheological properties of proteoglycan aggregates were studied over the concentration range 0.1–2.0 g/100 ml. Aggregate formation of proteoglycan monomer with hyaluronic acid increased the dependence on shear rate and shifted the Newtonian region to lower shear rates, compared to that observed with a proteoglycan monomer solution at the same concentration. The dynamic viscoelasticity also increased. In the presence of the link protein there is no Newtonian flow region over the shear rate ranges at a concentration of 1 g/100 ml or above and the value of the loss tangent remained low over the angular frequencies examined. Link protein strengthens the intermolecular interactions increasing the relaxation time of the aggregate solution. It increases the co-operativity of the binding of the proteoglycan monomers to the hyaluronic acid chain allowing a dynamic network structure to be developed in solution. The rheology is strongly dependent on the weight ratio of the proteoglycan to hyaluronic acid. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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