Synthesis of New Substituted 2-amino-4H-benzo[h]chromene-3-carbonitrile Derivatives

Autor: Ju Liu Ju Liu, Jian Tao Shi Jian Tao Shi, Xue Chen Hao Xue Chen Hao, Yu Tong Liu Yu Tong Liu, Shi Ding Shi Ding, Yang Wang and Ye Chen Yang Wang and Ye Chen
Rok vydání: 2019
Předmět:
Zdroj: Journal of the chemical society of pakistan. 41:888-888
ISSN: 0253-5106
DOI: 10.52568/000795/jcsp/41.05.2019
Popis: A series of novel substituted 2-amino-4H-benzo[h]chromene-3-carbonitrile derivatives was synthesised by condensation of different halogen derivatives with the hydroxy-group of 2-amino-8-hydroxy-4-styryl- 4H-benzo[h]chromene-3-carbonitrile and 2-amino-8-hydroxy-4- phenethyl-4H-benzo-[h]chromene-3-carbonitrile, which were prepared from cinnamaldehyde, malononitrile and naphthalene-1,6-diol through Knoevenagel condensation and cyclization reaction and then reduction with hydrogen in the presence of Pd/C at room temperature. Each intermediates and target compounds were obtained in good yields.
Databáze: OpenAIRE