Stabilization of Cyclic β-Hairpins by Ugi-Reaction-Derived N-Alkylated Peptides: The Quest for Functionalized β-Turns

Autor:	Daniel G. Rivera, Ludger A. Wessjohann, Aldrin V. Vasco, Manuel G. Ricardo
Rok vydání:	2019
Předmět:	chemistry.chemical_compound Dipeptide chemistry Stereochemistry Organic Chemistry Ugi reaction Physical and Theoretical Chemistry Alkylation Antiparallel (biochemistry) Biochemistry
Zdroj:	Organic Letters. 21:7307-7310
ISSN:	1523-7052 1523-7060
Popis:	A solid-phase approach including on-resin Ugi reactions was developed for the construction of β-hairpins. Various N-alkylated dipeptide fragments proved capable of aligning antiparallel β-sheets in...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::318e80185c8e95ca1e0f1bad4feb2da2 https://doi.org/10.1021/acs.orglett.9b02592 Zobrazit plný text záznamu