| Popis: |
In spite of considerable advances, understanding the mechanisms that regulate correct temporal and spatial gene expression during development remains one of the major challenges of molecular biology. During cardiac development, intricate patterns of gene expression underlie the processes of precursor cell specification and differentiation. Subsequent alterations in expression can be identified that correlate both with the formation of distinct cell types, including ventricular, atrial, and conduction system myocytes, and with the general process of myocyte maturation. One approach to identifying mechanisms that regulate these processes is through the dissection of specific regulatory pathways required for expression of particular genes, and this has led to the identification of a number of important transcriptional pathways. We have chosen to investigate the regulation of expression of troponin genes in the human heart as a route to identifying such pathways. |
