Europium complexes of 1,10-phenanthrolines: Their inclusion in liposomes and cytotoxicity

Autor:	E.V. Moiseeva, Nedyalko Lesev, G. P. Gaenko, Aleksey Vasilev, Julian G. Molotkovsky, Stefka Kaloyanova, Todor Deligeorgiev, Ivan A. Boldyrev
Rok vydání:	2011
Předmět:	Antitumor activity Liposome Chemistry Organic Chemistry Intercalation (chemistry) chemistry.chemical_element Pharmacology medicine.disease Biochemistry Molecular biology Lymphoma In vivo medicine Cytotoxic T cell Cytotoxicity Europium
Zdroj:	Russian Journal of Bioorganic Chemistry. 37:364-368
ISSN:	1608-330X 1068-1620
DOI:	10.1134/s106816201103006x
Popis:	Cytotoxic effect of a series of 1,10-phenanthroline coordination complexes with europium tris-β-diketonate (EuCs) against HBL-100 human breast carcinoma cells was determined. Cytotoxicity of liposomal formulation of V12, the most active EuC, was also studied. In vivo testing of this formulation on a started ASF-LL lethal murine model of T-cell leukemic lymphoma showed that the inclusion of V12 in liposomes did not result in enhancement of its antitumor activity in a local mode of administration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3175ef3a971cd9dc22f31913c5700c53 https://doi.org/10.1134/s106816201103006x Zobrazit plný text záznamu Full text from SpringerLink