Comparison of Cytur Test and Chemstrip Ln for Detecting Neutrophils in CAPD-Effluents
| Autor: | Pedersen Fb, Palle Wang, Antonsen S |
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| Rok vydání: | 1990 |
| Předmět: | |
| Zdroj: | Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis. 10:310-310 |
| ISSN: | 1718-4304 0896-8608 |
| Popis: | Sir: The Cytur-testR (Boehringer-Mannheim), origi nally developed for detection of leukocyturia (1), has become widely used for assisting in the diagnosis of peritonitis in CAPD. In a recent study of patients testing their dialysis effluent at home, it was concluded that the Cytur-test constitutes a valuable tool in the early detection of peritonitis (2). However, the reaction is relatively slow and faster modifications have been developed such as the Chemstrip LNR (Boehringer-Mannheim) (reaction time 1-2 min). We performed a comparison of the two test-strips on 77 bags with dialysis effluent from 30 patients in CAPD treatment. The strips were handled and read by trained technicians according to the recommendations of the manufacturer. The results are given in Table 1. The number of patients with a clinical diagnosis of peritonitis within each group is given in parenthesis. Although agreement between the 2 test strips was statistically significant (kappa = 0.62185, 2 p = 0.0003) (4), it was not complete. The Chemstrip LN did not react in 2 of the 10 patients with peritonitis. In contrast, the Cytur-test was positive in all of these patients. This is in accordance with Hurley et at. (5) who found that the predictive value of a negative test was 100%. The Cytur-test reacted positively with samples from six patients, who did not have peritonitis: a false positive test-rate of 0.375. Most of these patients were not typical however. One patient with a neutrophil count of 0.8 X 108/L was recovering from peritonitis, while four samples (3.8, 1.4, 0.5, and 0.2 x 108/L, respectively) were collected from patients on the very first morning following start of CAPD treatment. Thus, only one sample (with 2.3 X 108/L neutrophils) was found by accident in a patient without peritonitis or other cause of granulocytosis. The Cytur-test is an easy and cheap bed-side test which excludes peritonitis well. The Chemstrip LN seems to be less efficient in detecting peritonitis in CAPD although our material, admittedly, is small. Thus, despite a faster test strip would be convenient, we hesitate to replace the Cytur-test with any other test strip at the moment. |
| Databáze: | OpenAIRE |
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