FSH Stimulation of cAMP Accumulation in Hamster Sertoli Cells: Effect of Age and Optic Enucleation
| Autor: | Ron Philo, Albert S. Berkowitz, James P. Preslock, Jerrold J. Heindel |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
endocrine system
medicine.medical_specialty urogenital system Urology Endocrinology Diabetes and Metabolism Enucleation Hamster Stimulation Biology Sertoli cell Andrology Endocrinology medicine.anatomical_structure Reproductive Medicine Internal medicine medicine Spermatogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Andrology. 2:217-221 |
| ISSN: | 0196-3635 |
| Popis: | Sertoli cells isolated from immature, adult, and adult optic-enucleated hamsters respond to FSH, but not to LH, with an increase in cAMP accumulation. There is an age-related decline in responsiveness of Sertoli cells to FSH. Sertoli cells cultured from optic-enucleated adult hamsters with regressed testes respond to FSH with an Increased accumulation of cAMP similar in magnitude to that of immature Sertoli cells. These data indicate that optic enucleatlon results in a reversal of the sensitivity of Sertoll cells to FSH, an effect which may be important for the reinitiation of spermatogenesis, which naturally follows the regressed state. |
| Databáze: | OpenAIRE |
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