Reduced PD-1/PD-L1 expression in KRAS-mutant versus wild-type microsatellite instable (MSI-H) colorectal cancer (CRC) and association of wnt pathway corepressor TLE-3

Autor:	Aarti K. Bhatia, Raji Shameem, Julie Innocent, Sergei I. Grivennikov, Namrata Vijayvergia, Zoran Gatalica, Wafik S. El-Deiry, Joanne Xiu
Rok vydání:	2015
Předmět:	Cancer Research Colorectal cancer Mutant Wnt signaling pathway Wild type Biology medicine.disease medicine.disease_cause digestive system diseases Oncology Immunology medicine Cancer research Microsatellite Pd l1 expression KRAS neoplasms Corepressor
Zdroj:	Journal of Clinical Oncology. 33:3611-3611
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2015.33.15_suppl.3611
Popis:	3611 Background: MSI-H CRC comprises ~15% of CRC & has higher PD-1 & PD-L1 (P(+)) expression in CD4+ lymphocytes & tumor cells, respectively, compared to non-MSI-H CRC. Immune-checkpoint inhibitor ...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3169892cc10950ffb7dd41f00053a8e6 https://doi.org/10.1200/jco.2015.33.15_suppl.3611 Zobrazit plný text záznamu