Reduced Folate, Increased Vitamin B12 and Homocysteine Concentrations in Women Delivering Preterm
| Autor: | Savita Mehendale, Madhavi Dhobale, Hemlata Pisal, Asmita Kulkarni, Sadhana Joshi, Preeti Chavan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pregnancy
Nutrition and Dietetics Homocysteine business.industry Maternal Nutritional Physiological Phenomena Birth weight Medicine (miscellaneous) Physiology medicine.disease Micronutrient chemistry.chemical_compound Biochemistry chemistry Medicine Vitamin B12 Young adult business Increased vitamin B |
| Zdroj: | Annals of Nutrition and Metabolism. 61:7-14 |
| ISSN: | 1421-9697 0250-6807 |
| Popis: | Background and Aim: Maternal nutrition is an important determinant of the duration of pregnancy and fetal growth, and thereby influences pregnancy outcome. Folic acid and vitamin B12 are involved in one-carbon metabolism and are reported to underlie intrauterine programming of adult diseases. Methods: In the present study, the levels of folate, vitamin B12 and homocysteine were measured in mothers delivering preterm (PT; gestation Results: Increased vitamin B12 and homocysteine levels (p < 0.05 for both) were seen in the PT-PE and PT groups as compared to the controls. In addition, reduced folate levels (p < 0.05) were observed in the PT group. A negative association of maternal plasma homocysteine with birth weight was seen in the idiopathic preterm group. Conclusions: Altered maternal micronutrients and resultant increased homocysteine concentrations exist in women delivering preterm. These alterations may also be partly associated with other factors such as undiagnosed inflammatory conditions or inadequate placentation in some women. Since these micronutrients play an important role in epigenetic regulation of vital genes involved in the fetal programming of adult diseases, further studies need to be undertaken to understand their role in preterm deliveries. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|