Silymarin as a therapeutic extract for intestinal and splenic injuries induced by microcystin-LR in mice
| Autor: | Ayman Al-Hazmi, Leila Ait Abderrahim, Anas M. Alomery |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Multidisciplinary
Antioxidant Toxin medicine.medical_treatment Methylglyoxal Phosphatase Microcystin-LR 02 engineering and technology Glutathione 010501 environmental sciences Pharmacology 021001 nanoscience & nanotechnology medicine.disease_cause 01 natural sciences chemistry.chemical_compound chemistry Splenic Tissue medicine 0210 nano-technology 0105 earth and related environmental sciences Silybum marianum extract |
| Zdroj: | Journal of King Saud University - Science. 31:1414-1417 |
| ISSN: | 1018-3647 |
| Popis: | Introduction Microcystin-LR is a toxic compound produced by Cyanobacteria and responsible for to destruction of different types of human and animal tissues. These damages are treated by different flavonoids such as silymarin. Silymarin is a Silybum marianum extract that has antioxidant, anti-inflammatory and anticancer functions. Materials and methods Sixty male Balb/c mice 5–7 weeks-old classified into six groups; control (C), two toxin control groups (M6 and M12), silymarin control group (S) and two toxin silymarin groups SM6 and SM12. Blood samples were collected from each mousefor serum transaminases measurement. Intestinal and splenic homogenates were used for measurement of reduced glutathione (GSH), protein carbonyl derivative oxidation (CC), lipid peroxidants (LPO) and methylglyoxal (MG). Results Transaminases showed significant statistical differences between all six groups. Moreover, significant statistical differences were observed in PPI, GSH, LPO, CC and MG between six groups in Intestinal tissue. On splenic tissue, significant statistical differences were observed only in PPI and CC. Conclusion Silymarin has an antioxidant by induction of protein phosphatase I activity and increases reduced glutathione in microcystin-LR induced intestinal and splenic injuries. |
| Databáze: | OpenAIRE |
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