Water-Soluble Form of 1-Alkyl(Aryl)Imidazole-4,5-Dicarboxylic Acids. Structure and Anticonvulsant Activity of the Triethanolammonium Salt of 1-Propylimidazole-4,5-Dicarboxylic Acid

Autor:	Andrey A. Zolotarev, V. S. Fundamenskii, D. N. Nikolaev, A. V. Selitrenikov, S. M. Ramsh, A. M. Potapkin, Yu. E. Zevatskii, L. B. Piotrovskii, V. V. Gurzhii, M. A. Brusina
Rok vydání:	2018
Předmět:	Pharmacology chemistry.chemical_classification 010405 organic chemistry medicine.medical_treatment Aryl Salt (chemistry) Crystal structure 010402 general chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Dicarboxylic acid Anticonvulsant chemistry Drug Discovery Convulsant medicine Imidazole Alkyl
Zdroj:	Pharmaceutical Chemistry Journal. 52:299-303
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-018-1810-9
Popis:	Water-soluble forms of a series of 1-alkyl(aryl)imidazole-4,5-dicarboxylic acids were prepared. Anticonvulsant activity of 1-propylimidazole-4,5-dicarboxylic acid and its triethanolammonium salt was studied using the NMDA-induced convulsion model. The triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid was shown to possess anticonvulsant activity whereas the acid itself was a convulsant. The change of pharmacological profile was related to the formation of ion pairs or associates even in polar physiological media. The ability to associate was confirmed using conductivity measurements. An x-ray crystal structure analysis was performed for the triethanolammonium salt of 1-propylimidazole-4,5-dicarboxylic acid.
Databáze:	OpenAIRE
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