Biocompatibility of Modified Bionanocellulose and Porous Poly(ϵ-caprolactone) Biomaterials

Autor:	Karolina Kowalska-Ludwicka, Agnieszka Adamus, Radoslaw A. Wach, Stanisław Bielecki, Zbigniew Pasieka, Marek Kolodziejczyk, Janusz M. Rosiak, Bartlomiej Grobelski, Alicja Olejnik
Rok vydání:	2014
Předmět:	Materials science Polymers and Plastics Biocompatibility General Chemical Engineering Inflammation ϵ caprolactone In vitro Analytical Chemistry In vivo medicine medicine.symptom Cytotoxicity Porosity Biomedical engineering Explant culture
Zdroj:	International Journal of Polymeric Materials and Polymeric Biomaterials. 63:518-526
ISSN:	1563-535X 0091-4037
DOI:	10.1080/00914037.2013.854223
Popis:	Biocompatibility of modified bionanocellulose (BC) and porous poly(ϵ caprolactone) (PCL) were compared to UHMWPE. For all the materials lack of cytotoxic effect to mouse fibroblasts was observed in vitro. In vivo study, subcutaneous implantations in Wistar rats, lasted for seven, 14, and 30 days. Subsequently the composition of surrounding tissue and explants surface changes was evaluated. No symptoms of acute inflammation were observed. Surrounding tissue thickness, the number of granulocytes, lymphocytes, macrophages, and blood vessels differed in time and revealed regular healing process. It is concluded that investigated PCL and BC are the materials with superior biocompatibility with high application potential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31538c739adf0dc999e8d9e00ee949e1 https://doi.org/10.1080/00914037.2013.854223 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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