Synthesis of 2-amino-4-phenylthiazole-derived thiuram disulfide

Autor:	L. K. Abulyaissova, S. O. Kenzhetaeva
Rok vydání:	2013
Předmět:	Cationic polymerization chemistry.chemical_element General Chemistry 2-amino-4-phenylthiazole Tetramethylthiuram disulfide Sulfur Combinatorial chemistry chemistry.chemical_compound chemistry Chronic alcoholism Disulfiram Thiuram disulfide medicine Amine gas treating medicine.drug
Zdroj:	Russian Journal of General Chemistry. 83:2115-2116
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363213110285
Popis:	Thiuram disulfides, many of them revealing various utilitarian properties, are among the most important classes of organic sulfur compounds. For instance, tetraethylthiuram disulfide (Teturam, Disulfiram) is used in medicine to treat chronic alcoholism, and tetramethylthiuram disulfide accelerates rubber cooling and has been intensively applied in the industry [1]. Tetramethylthiuram disulfide is used in preparation of antihypertensive drug clonidine as well. N,N-Bis(vinyloxyethyl)thiuram disulfide homopolymer obtained by cationic polymerization is a selective adsorbent of mercury and noble metals [2]. Despite the wide range of thiuram disulfides applications, only a limited number of such amine derivatives have been investigated so far. Therefore, it is of potential practical interest to synthesize thiuram disulfide based on 2-amino-4-phenylthiazole; that amine has been selected due to various pharmacological activities of the thiazoles: antiviral, anti-parasitic, and anti-pyretic drugs [3] are among other examples.
Databáze:	OpenAIRE
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