Synthesis and characterization of novel spirooxazacamphorsultam derivatives

Autor:	Effrat L. Fayer, M. Leigh Abrams, Erika N. Cline, Burkhardt I. Wilke, Diana M. Cermak, Angela K. Goodenough, Cory C. Bausch
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Ketone Organic Chemistry Imine Acetal Camphorsultam Enantioselective synthesis Biochemistry chemistry.chemical_compound chemistry Yield (chemistry) Drug Discovery Organic chemistry Moiety Two-dimensional nuclear magnetic resonance spectroscopy
Zdroj:	Tetrahedron Letters. 51:6871-6873
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2010.10.105
Popis:	Derivatives of camphorsultam which contain novel spirooxazolidine and spirooxazine structures have been prepared in high yield and purity. Though it was expected that the ketone moiety would undergo acetal formation, the imine instead underwent reaction and was proven by X-ray crystallography and 2D NMR techniques. The initial ketone-containing derivatives were then reduced to produce exo-hydroxy analogs that have potential as a new family of chiral auxiliaries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::31443351ebd747a18348414461cc85ee https://doi.org/10.1016/j.tetlet.2010.10.105 Zobrazit plný text záznamu Full Text from ScienceDirect