| Autor: |
Sulaimon, Ayodele O., Auta, Timothy, Hassan, Amusat T. |
| Rok vydání: |
2015 |
| Předmět: |
|
| DOI: |
10.5281/zenodo.216764 |
| Popis: |
The study aimed to evaluate the antidiabetic effect of Irvingia gabonensis leaf and bark extracts on alloxan induced diabetic rats. Forty-four healthy rats were used in the experiment; they were grouped into eight groups. Alloxan was injected intraperitoneally and increase in the blood sugar level was confirmed after three days with glucometer (AccuCheck). The aqueous and ethanolic extracts of both leaf and bark at 150 and 250 mg/kg were orally administered daily for 16 days. Blood sugar level and body weight of each group were monitored and haematological parameters determined at the end of the experiment. Diabetic groups to which aqueous leaf extract at doses of 150 mg/l and 250 mg/l were administered showed significant decrease in blood sugar level from 463.50±29.32 and 381.33±39.77 to 103.50±4.50 and 97.00±2.00 respectively, compared to the positive group treated with glibenclamide, 468.67±30.82 to 86.67±2.73 (PIrvingia gabonensis had more anti-diabetic activity than the ethanolic extracts. They also improved the haematological indices of the treated animals. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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