Fibroblasts as the subject of proliferative activity research in vitro
| Autor: | Elena V. Avdeeva, Natalya A. Kolotieva, I. M. Bykov, Valeriya I. Kuzmicheva, F.N. Gilmiyarova, Larisa T. Volova |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chemistry Cell Biological activity Malate dehydrogenase In vitro Cell biology 03 medical and health sciences Cytosol 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Enzyme Cell culture medicine General Earth and Planetary Sciences Fibroblast 030217 neurology & neurosurgery General Environmental Science |
| Zdroj: | Science and Innovations in Medicine. 5:210-215 |
| ISSN: | 2618-754X 2500-1388 |
| DOI: | 10.35693/2500-1388-2020-5-3-210-215 |
| Popis: | This review presents the data devoted to anatomical and functional diversity of fibroblasts, peculiarities of metabolic processes and energy exchange in these cells. In particular, the changes in fibroblast proliferative activity depending on various factors are discussed. The review shows the influence of the malate dehydrogenase shuttle system on the activity of metabolic processes and the life span of fibroblastsin vitro. The increase of cell cultivation timein vitrois associated with the cytosolic isoform of this enzyme. The stability of fibroblast cell culture to the activation of free-radical processes and peroxidation with addition of biologically active compounds is described and followed by a discussion of the role of separate metabolites in providing free-radical protection and maintenance of the proliferative potential of cells. |
| Databáze: | OpenAIRE |
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