Hyaluronidase-Inhibiting Polysaccharide Isolated and Purified from Hot Water Extract of Sporophyll of Undaria pinnatifida
| Autor: | Takuya Katsube, Syuichi Oka, Yukikazu Yamasaki, Masatoshi Iwamoto |
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| Rok vydání: | 2003 |
| Předmět: |
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chemistry.chemical_classification Chromatography General Chemical Engineering Extraction (chemistry) Sulfuric acid Undaria pinnatifida Polysaccharide Industrial and Manufacturing Engineering chemistry.chemical_compound Column chromatography Sulfation chemistry Biochemistry Hyaluronidase medicine Sporophyll Food Science Biotechnology medicine.drug |
| Zdroj: | Food Science and Technology Research. 9:25-29 |
| ISSN: | 1881-3984 1344-6606 |
| DOI: | 10.3136/fstr.9.25 |
| Popis: | Polysaccharide showing inhibitory activity against hyaluronidase, which is known to be related to inflammation and tumor metastasis, was purified from the sporophyll of Undaria pinnatifida by fractionated extraction and column chromatography. On the basis of chemical analyses, the purified compound was found to be a kind of sulfated polysaccharide. The molar ratio of sugars and sulfuric acid in the purified compound was estimated to be L-fucose : D-galactose : D-glucuronic acids : sulfuric acid1.0 : 1.0 : 0.04 : 5.2. The number-average molecular weight of the sulfated polysaccharide was estimated to be 63,000 by high-performance liquid chromatography. This polysaccharide inhibited hyaluronidase activity (IC5013.0 μg/ml) in a dose-dependent manner. |
| Databáze: | OpenAIRE |
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