Leptin: A pubertal hormone in obese and non-obese children? • 15

Autor:	Elizabeth de Lancey, Kimberly A. Soisson, Jaquelyn M. Brown, Robert V. Considine, Sandra G. Hassink, Karen Oerter Klein
Rok vydání:	1997
Předmět:	medicine.medical_specialty Pregnancy business.industry Insulin medicine.medical_treatment Leptin digestive oral and skin physiology Bone age medicine.disease Pubertal stage Endocrinology Non obese Internal medicine Pediatrics Perinatology and Child Health medicine business Body mass index Hormone
Zdroj:	Pediatric Research. 41:5-5
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199704001-00036
Popis:	Background: Studies in ob/ob, leptin deficient, mice have shown that leptin is necessary for progression through puberty, pregnancy, and parturition. Obese children progress through puberty at earlier ages than non-obese children. Studies in children have shown that leptin concentrations are greater in early puberty than in adults independent of adiposity. Objective: To investigate the 24 hour secretory profile of leptin in obese and non-obese children in early puberty and to measure bone age (BA). Design: Eighteen obese (12F:6M) and 30 non-obese (11F:19M) children in early puberty (pubertal stages 1-2) were admitted overnight for hourly measurement of serum leptin, insulin, and glucose. Bone age was obtained upon completion of the 24 hour study. Results: Mean fasting leptin concentrations were significantly increased in the obese group (26.3 ng/ml) compared to controls (5.9 ng/ml), and correlated with Body Mass Index(BMI) (r=0.82) and arm fat (r=0.87). When statistically controlling for adiposity, there was no difference in mean leptin levels in obese vs. control children. Female leptin concentrations (12.78 ng/ml) were significantly(p
Databáze:	OpenAIRE
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