Synthesis and Physiological Genetic Effects of 1-(Methacryloyloxyethyl)- 5-Fluorouracil and Its Polymers
| Autor: | Won Jei Cho, Chang-Sik Ha, Neung Ju Lee, Ik Sung Kim, Won Moon Choi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics 0206 medical engineering Radical polymerization Bioengineering 02 engineering and technology Polymer Biology 021001 nanoscience & nanotechnology Methacrylate 020601 biomedical engineering Biomaterials chemistry.chemical_compound Monomer chemistry Fluorouracil Polymer chemistry Materials Chemistry medicine Reactivity (chemistry) 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Bioactive and Compatible Polymers. 7:39-53 |
| ISSN: | 1530-8030 0883-9115 |
| DOI: | 10.1177/088391159200700105 |
| Popis: | The monomer 1-(methacryloyloxyethyl)-5-fluorouracil (MAO EFU) was synthesized from 2,4-bis(trimethylsilyloxy)-5-fluoropyrimidine. Poly- (MAOEFU) and poly(MAOEFU-co-methyl methacrylate) were obtained by radical polymerization at 60°C. The monomer reactivity ratios, r1 and r2 were determined by the Kelen-Tüdös method; r, (MAOEFU) = 0.77 and r2(MMA) = 1.13. The physiological genetic effect of MAOEFU and its polymers in Dro sophila melanogaster was investigated and found that MAOEFU, poly- (MAOEFU) and poly(MAOEFU- co-MMA) are considerably less effective than 5- fluorouracil. |
| Databáze: | OpenAIRE |
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