Methods of producing high specific activity Sn-117m with commercial cyclotrons
| Autor: | Nigel R. Stevenson, St George George, Gilbert Gonzales, R. Keith Frank, Suresh C. Srivastava, Jason Rogers, Ian M. Horn, Jaime Simon, David Mueller |
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| Rok vydání: | 2015 |
| Předmět: |
Isotope
Health Toxicology and Mutagenesis Radiochemistry Cyclotron Public Health Environmental and Occupational Health Conjugated system Pollution Analytical Chemistry law.invention chemistry.chemical_compound Nuclear Energy and Engineering chemistry High specific activity law DOTA Radiology Nuclear Medicine and imaging Chelation Purification methods Spectroscopy Derivative (chemistry) |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 305:99-108 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | Sn-117m is a theragnostic isotope of increasing interest. It has ideal imaging and therapeutic properties for many applications. Production of high specific activity Sn-117m can only be achieved with accelerators and the Sb(p,x) and Cd-116(α,3n) reactions provide the highest yields for this isotope. This paper describes the production and a new purification method for obtaining commercial quantities of Sn-117m via the Cd-116(α,3n) reaction. The purified Sn-117m has subsequently been chelated with an aminobenzyl derivative of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and then conjugated with annexin V-128 to produce an agent for the diagnosis and treatment of vulnerable plaque. |
| Databáze: | OpenAIRE |
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