Antimycobacterial Activity of Milemaronol, a New Squalene-Type Triterpene, and Other Isolate?
| Autor: | Raimundo Braz-Filho, Ivo José Curcino Vieira, Lara F. Barbosa Siqueira, Michel de Souza Passos, Mariana Félix, Sanderson Dias Calixto, Michelle Frazão Muzitano, Samyra Imad da Silva Boeno, Almir Ribeiro Carvalho Junior |
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| Rok vydání: | 2020 |
| Předmět: |
Pharmacology
chemistry.chemical_classification biology Traditional medicine 010405 organic chemistry medicine.drug_class Plant Science General Medicine biology.organism_classification Antimycobacterial 01 natural sciences 0104 chemical sciences Terpene 010404 medicinal & biomolecular chemistry Squalene chemistry.chemical_compound Complementary and alternative medicine chemistry Triterpene Scopoletin Drug Discovery medicine Quassinoid Simaroubaceae Mycobacterium |
| Zdroj: | Natural Product Communications. 15:1934578X2092558 |
| ISSN: | 1555-9475 1934-578X |
| Popis: | A new triterpene, named milemaronol (1), was isolated from Homalolepis suffruticosa Engl., Simaroubaceae, along with 10 known metabolites, chaparrinone (2), scopoletin (3), 5-methoxycanthin-6-one (4), eurylene (5), hispidol A (6), hispidol B (7), nilocitine (8), α-dihydronylocytine (9), β-dihydronylocytine (10), and teurilene (11). These compounds were characterized based on their spectral data, mainly 1D (1H, 13C-APT) and 2D (1H-1H-COSY, NOESY, HSQC, HMBC) NMR and their mass spectra (HR-ESI-MS), in comparison with data from the literature. Compounds 1 to 6, 8, and 9 were evaluated for their antimycobacterial activity against 2 strains (H37Rv and M299). |
| Databáze: | OpenAIRE |
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