An unusual oxidation of thiazol-2-ylmethanol in hydrolytic conditions

Autor:	Giacomo Mauriello, Maurizio D'Auria, Rocco Racioppi
Rok vydání:	1999
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Hydrolysis Ketone chemistry Aryl Reagent Thiazoline chemistry.chemical_element Organic chemistry Sulfuric acid Oxygen
Zdroj:	Journal of the Chemical Society, Perkin Transactions 1. :37-40
ISSN:	1364-5463 0300-922X
Popis:	The treatment of aryl and heteroaryl thiazol-2-ylmethanols with sulfuric acid in a dimethoxyethane–water mixture at 80 °C gave the corresponding ketone as the only product in good yields. All the data are in agreement with a mechanism involving the formation of a thiazoline as intermediate. Best yields can be obtained carrying out the reaction in the presence of oxygen, showing that this reagent oxidizes the thiazoline intermediate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::30f9cc6db1efd98d8b8a338cede3cd32 https://doi.org/10.1039/a807481j Zobrazit plný text záznamu