Endobronchial Lesions from Disseminated Mycobacterium avium Infection in a Patient with Anti-interferon-gamma Autoantibodies
| Autor: | Dai Hashimoto, Masato Kono, Hidenori Nakamura, Akari Tsutsumi, Ryutaro Hirama, Yuiko Ohshima, Kenichiro Takeda, Yoshihiro Miki, Toshiki Kimura, Hideki Miwa, Yasutaka Mochizuka, Takuro Sakagami |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Lung Mediastinal lymphadenopathy medicine.diagnostic_test business.industry Mycobacterium Avium Infection Autoantibody General Medicine respiratory system 030204 cardiovascular system & hematology medicine.disease Chest pain 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Biopsy Internal Medicine medicine 030211 gastroenterology & hepatology Interferon gamma Endobronchial Lesion medicine.symptom business medicine.drug |
| Zdroj: | Internal Medicine. 60:3267-3272 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A 78-year-old man was admitted to our hospital with a fever and left chest pain. Computed tomography showed multiple lung nodules, narrowing of the right bronchus intermedius with mediastinal lymphadenopathy, and an osteolytic lesion. Bronchoscopic findings showed rapid progression of multiple polypoid lesions and the bronchial stenosis. A biopsy of the endobronchial lesions revealed non-necrotizing granulomatous inflammation, and a tissue culture identified Mycobacterium avium. An anti-human immunodeficiency virus antibody was negative. Finally, anti-interferon-gamma (IFN-γ) autoantibodies were detected, and the patient was diagnosed with disseminated nontuberculous mycobacterium infection with anti-IFN-γ autoantibodies. Antimycobacterial therapy was effective, and radiographic findings, including the endobronchial lesions, were resolved. |
| Databáze: | OpenAIRE |
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