Serum Level of Vitamin C in a Sample of Egyptian Patients with Multiple Sclerosis
| Autor: | Asmaa Ibrahim, Mohamed Hamdy, Mohamed M. Fouad, Taha K Alloush, Yousry Abo Elnaga |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Neuroscience and Medicine. 10:398-406 |
| ISSN: | 2158-2947 2158-2912 |
| DOI: | 10.4236/nm.2019.104029 |
| Popis: | Background: Antioxidants such as vitamin C can eliminate free radicles responsible for oxidative stress. Objective: To assess the serum level of vitamin C in a sample of multiple sclerosis (MS) patients to investigate a possible role of vitamin C in the pathogenesis of MS. Subjects and Methods: Forty patients with MS and twenty healthy controls were included in this study. Vitamin C level was estimated for each participant. Results: Serum vitamin C levels were significantly lower among the patients (ranging from 0.28 mg/dL to 0.75 mg/dL with mean 0.47 ± 0.14 mg/dL and median of 0.46 mg/dL) compared to controls (ranging from 0.60 mg/dL to 2.90 mg/dL with mean 1.87 ± 0.61 mg/dL and median of 1.90 mg/dL) (P < 0.001). A positive correlation was detected between age and serum vitamin C (r = 0.312, P = 0.049). Patients with infratentorial lesions had significantly lower levels of serum vitamin C compared to those who did not have infratentorial lesions (P = 0.017). Conclusion: Patients with MS tended to have low serum vitamin C levels, and younger patients had lower serum levels. |
| Databáze: | OpenAIRE |
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