High-Intensity Interval Training and Intake nano-selenium supplementation on the gene expression of hepatic SOD and CAT in Dexamethasone Induced Rats

Autor: Motahare ghane, Shahin Riyahi Malayeri, Masume Hoseini
Rok vydání: 2023
DOI: 10.21203/rs.3.rs-2644614/v1
Popis: Dexamethasone is one of the glucocorticoids which leads to oxidative damage. Therefore, antioxidants can reduce tissue toxicity to prevent the increase in oxidative stress caused by dexamethasone. The present study examines the effect of high-intensity interval training (HIIT) and nano-selenium supplementation on the expression of hepatic superoxide dismutase (SOD) and catalase (CAT) genes in dexamethasone-induced rats. The samples were 40 Wistar rats in the age range of 8 weeks, which were randomly divided into 5 groups of 8 (healthy, induced by dexamethasone, dexamethasone+HIIT, dexamethasone+nano-selenium supplementation, dexamethasone+HIIT+nano-selenium supplementation). The exercise program was performed six days a week for four weeks. The prepared stock solution of selenium nanoparticles was given to mice in the amount of 100 mg by gavage every other day. A two-way analysis of covariance was used to determine the difference in variables between groups at a significant level (P
Databáze: OpenAIRE