ChemInform Abstract: New 2′-C-Branched-Chain Sugar Nucleoside Analogs with Potential Antiviral or Antitumor Activity

Autor:	Claude Monneret, J.‐C. Florent, David S. Grierson, Jean-Marc Jarrige, Jean-Pierre Wolf
Rok vydání:	2010
Předmět:	Antitumor activity Substitution reaction Nucleoside analogue Stereochemistry General Medicine Thymine chemistry.chemical_compound chemistry Chain (algebraic topology) Nucleic acid medicine Purine derivative Sugar medicine.drug
Zdroj:	ChemInform. 23
ISSN:	0931-7597
Popis:	The synthesis of 2'-C-hydroxymethyl and 2'-C-methyl nucleoside analogs [1-(3-deoxy-2-hydroxymethyl-D-erythro-pentofuranosyl)-thymine , the corresponding adenine derivative. 1-(2-methyl-β-D-ribofuranosyl)thymine and 2'-methyladenosine ] by coupling of sugar moieties, easily prepared from α-D-isosaccharino-and α-D-glucosaccharino-1,4-lactone derivatives, respectively, with silylated thymine or 6-chloropurine is reported
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::30e583dfc62f4fb5e7cdae7dae68ff19 https://doi.org/10.1002/chin.199250279 Zobrazit plný text záznamu Plný text