Enantioselective synthesis of α-hydroxyacids through oxidation of terminal alkenes with AD-mix/TEMPO

Autor:	Jesus M. Bustamante, Guillermo M. Massanet, Zacarías D. Jorge, F. Javier Aladro, Francisco M. Guerra, F. Javier Moreno-Dorado
Rok vydání:	2000
Předmět:	chemistry.chemical_classification Fragmentation (mass spectrometry) Chemistry Dihydroxylation Alkene Organic Chemistry Drug Discovery Enantioselective synthesis Oxidation process Biochemistry Medicinal chemistry AD-mix
Zdroj:	Tetrahedron Letters. 41:3209-3213
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)00352-x
Popis:	α-Hydroxyacids can be enantioselectively prepared by means of a two-step oxidation process, involving first the asymmetric dihydroxylation of a terminal alkene and subsequent oxidation with TEMPO/NaOCl/NaClO 2 in good to excellent yields. No fragmentation of the glycol intermediate was detected.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::30e0a4806ea66cd17d1a57b5e6b3fd86 https://doi.org/10.1016/s0040-4039(00)00352-x Zobrazit plný text záznamu Full Text from ScienceDirect