ANTI-CANCER EFFECT OF PLANTAGO DEPRESSA ETHANOLIC EXTRACT IN B16F10 SKIN CANCER CELLS
| Autor: | N V Ay, Enkhchimeg, Altantsetseg Kh, Baatartsogt O |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
integumentary system
Lipopolysaccharide 030232 urology & nephrology Cancer Stimulation Inflammation 030204 cardiovascular system & hematology Biology Pharmacology medicine.disease In vitro 03 medical and health sciences HaCaT chemistry.chemical_compound 0302 clinical medicine chemistry medicine Viability assay Skin cancer medicine.symptom |
| Zdroj: | Mongolian Journal of Agricultural Sciences. 21:29-34 |
| ISSN: | 2524-0722 2310-6212 |
| DOI: | 10.5564/mjas.v21i02.902 |
| Popis: | Plantago depressa Willd. is a distributed herb which traditionally used for treating wound, fever, cancer and inflammation in some temperate asian countries. This present study aimed to investigate the anti-cancer activity of ethanol extract of Plantago depressa Willd. plant on B16F10 skin cancer cells. Cells were treated with different concentration of the PDE (25, 50, 100, 200 μg/mL) with or without lipopolysaccharide (LPS) stimulation to evaluate its effect on cell viability. Furthermore, anti-cancer activity was evaluated by checking viability of B16F10 skin cancer cells in various concentration of the PDE extract (0.6, 1.2, 2.5 and 5 μg/mL), using CCK-8 assay. The results indicated that (i) the PDE treatment did not influence on cell viability of HaCaT skin normal cells dose-dependently; and (ii) PDE exhibits anti-cancer activity through inhibition of proliferation of B16F10 skin cancer cells. |
| Databáze: | OpenAIRE |
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