ChemInform Abstract: Inhibition of Cryptosporidium parvum in vitro by 9-(Alkylthio)acridine Derivatives

Autor:	Maria‐Jose Rosales, Pierre Brouant, Carmen Mascaro, Nadia Bsiri, Latifa Khalifa, Janina Karolak-Wojciechowska, Jacques Barbe
Rok vydání:	2010
Předmět:	Cryptosporidium parvum biology Biochemistry Opportunistic infection Chemistry medicine Acridine derivatives General Medicine medicine.disease biology.organism_classification In vitro
Zdroj:	ChemInform. 31
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200021135
Popis:	The synthesis of several acridinic thioethers is described. Compounds prepared were tested in vitro as potential drugs against the opportunistic infection known as cryptosporidiosis. With a view to predict activity, the quantitative structure-activity relationships were investigated. Correlations between experimental data and either log P or pKa are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::30d736e5b44fb359beb96d0f71ad5596 https://doi.org/10.1002/chin.200021135 Zobrazit plný text záznamu Plný text