A human cell panel for evaluating safe application of nano-ZrO2/polymer composite in water remediation
| Autor: | Liwen Jiang, Hainan Sun, Cuijuan Jiang, Xiaokun Liu, Zhou Li, Jiahui Wang, Yi Zhang, Xueci Xing, Yabin Wang, Bingcai Pan, Wang Xiaoling, Bing Yan |
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| Rok vydání: | 2018 |
| Předmět: |
Pollutant
Chemistry Health Toxicology and Mutagenesis Groundwater remediation HEK 293 cells Public Health Environmental and Occupational Health Nanoparticle 02 engineering and technology General Medicine 010501 environmental sciences 021001 nanoscience & nanotechnology 01 natural sciences Pollution Nanomaterials Adduct Environmental chemistry Toxicity 0210 nano-technology Cytotoxicity 0105 earth and related environmental sciences |
| Zdroj: | Ecotoxicology and Environmental Safety. 166:474-481 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/j.ecoenv.2018.09.098 |
| Popis: | Nanomaterials, such as ZrO2 nanoparticles (ZrO2 NPs), are very effective in water remediation. However, the safety issues related to nanoparticle release and toxicity to humans remain to be resolved. Here we evaluated the cytotoxicity of ZrO2 NPs and their adducts with pollutants using a human cell panel containing stomach, intestine, liver and kidney cells. We found that different pollutants or ZrO2NP/pollutant adducts targeted cells from different organs, suggesting the necessity of a cell panel to model oral exposures. The cooperation of ZrO2 NPs and pollutants was quite complex, consisting of synergistic, antagonistic, or additive effects. For example, ZrO2 NPs enhanced the cytotoxicity of Pb2+ in GES-1 cells and of Pb2+, Cd2+ in FHC cells, while alleviating the toxicity of Pb2+ and As (III) in HepG2 and Hek293 cells. Our results also indicated that even concentrations of pollutants that meet the national standard, the ZrO2 NPs concentration should be kept below 17 μg/mL to avoid ZrO2 NP/pollutant adduct synergistic toxicity. |
| Databáze: | OpenAIRE |
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