Preparation and characterization of novel tamarind gum-based hydrogels for antimicrobial drug delivery applications
| Autor: | Suraj K. Nayak, Preetam Sarkar, Irshaan Syed, Kunal Pal, Vinay Singh, K. Senthilguru, Vivek Sharma, Goutam Thakur, Pallavi Patnaik |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Drug
General Chemical Engineering media_common.quotation_subject macromolecular substances 02 engineering and technology 010402 general chemistry Polysaccharide 01 natural sciences Biochemistry Industrial and Manufacturing Engineering Materials Chemistry Ionic conductivity Fourier transform infrared spectroscopy media_common chemistry.chemical_classification Chemistry technology industry and agriculture General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Characterization (materials science) Antimicrobial drug Chemical engineering Drug delivery Self-healing hydrogels 0210 nano-technology |
| Zdroj: | Chemical Papers. 72:2101-2113 |
| ISSN: | 1336-9075 2585-7290 |
| DOI: | 10.1007/s11696-018-0414-x |
| Popis: | Tamarind gum (TG) polysaccharide has shown great potential in food and pharmaceutical applications due to their viscosity-modulating properties. In this study, TG hydrogels of varied concentrations were developed by physical gelation method. The prepared hydrogels were characterized by microscopy, XRD, FTIR, mechanical, electrical and drug release studies. Microscopic studies showed formation of globular structures throughout the matrix. XRD and FTIR studies suggested an increase in the associative interactions when the TG content was increased, which in turn resulted in the alteration in the mechanical properties. An increase in the intrinsic ionic conductivity was predicted from the electrical studies. This increase in intrinsic ionic conductivity modulated the release of the drug from the hydrogels. The drug was released in its active form. In gist, it can be concluded that the physical hydrogels prepared using TG may be explored as matrices for drug delivery applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink