Pathogenesis of extrapulmonary organ damage in SARS-CоV-2 coronavirus infection (analytical review)
| Autor: | A. A. Kukhtina, A. V. Savin, A. S. Litvinov, D. A. Sitovskaya |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Transmission (medicine) viruses fungi 030106 microbiology virus diseases Outbreak Disease Biology medicine.disease medicine.disease_cause Virology Virus body regions 03 medical and health sciences Pneumonia 030104 developmental biology Nephrology Pandemic medicine skin and connective tissue diseases Viral load Coronavirus |
| Zdroj: | Nephrology (Saint-Petersburg). 25:18-26 |
| ISSN: | 2541-9439 1561-6274 |
| Popis: | Over the past two decades, coronavirus infection has caused two major pandemics: SARS in 2002 and acute respiratory syndrome (MERS) in the Middle East in 2012. In December 2019, the novel coronavirus (CV) SARS-CoV-2 caused an outbreak of pneumonia in Wuhan, China. Experts from the World Health Organization (WHO) have confirmed the risk of this disease for the public health of the entire planet. SARS-CoV-2 was isolated from epithelial cells of the human respiratory tract. It was found that the genotype KB SARS-CoV-2 is closer to bat-SL-CoVZC45 and bat-SL-CoVZXC21, and the spike glycoprotein (SB) of the virus, which determines the ability to bind to the cellular receptor, is similar to the SARS-CoV coronavirus, which is responsible for the outbreak of severe acute respiratory syndrome (SARS / SARS) in 2002]. Angiotensin-converting enzyme 2 (ACE2) is an endogenous spike protein (spike glycoprotein with the S-domain) SARS-CoV-2, which, as part of the ACE2 + SARS-CoV-2 complex, binds to the ACE2 receptor located on the target cell membrane. The article discusses the mechanisms of infection with SARS-CoV-2, cell-cell interactions, and transmission routes. The issues of the epidemiology of COVID-19 and the prospects for the involvement of organs and systems other than the respiratory one in maintaining the viral load are covered in detail. The problems of the immune defense of the human body during infection with SARS-CoV-2 have been identified. Clinical parallels with progenitor viruses, namely SARS-CoV-1 and MERS-CoV, have been drawn. Highlighted risk factors for SARSCoV- 2 infection, which make it possible to predict the nature of the course and probable outcomes of COVID-19. © 2021 Educational Autonomous Non-Profit Organization Nephrology. All Rights Reserved. |
| Databáze: | OpenAIRE |
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