Insulin Resistance may be a Central Pathogenetic Mechanism in the Development of Psoriatic Plaques
| Autor: | Claudia Bürger, Wolf-Henning Boehncke, Sandra Boehncke |
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| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Psoriasis Forum. :84-89 |
| ISSN: | 1557-3168 1089-3504 |
| DOI: | 10.1177/247553031218a00206 |
| Popis: | Background Insulin is a multifunctional hormone. It provides a link for the regulation of metabolic as well as nonmetabolic cells. Inefficient signal transduction (ie, insulin resistance) is the central pathomechanism in type 2 diabetes mellitus; it also drives atherosclerosis through induction of endothelial dysfunction. Objective Because epidermal homeostasis depends on insulin, too, we speculate on a potential role of insulin resistance in the formation of psoriatic plaques. Methods We comment on the effects of insulin on keratinocyte biology, with an emphasis on cytokine-induced insulin resistance in the light of recent original work from our group. Results There is increasing evidence for cytokine-induced insulin resistance in keratinocytes that contributes to the epidermal phenotype in lesional psoriatic skin. Conclusion Pro-inflammatory cytokines might induce a state of epidermal dysfunction, much like the state of endothelial dysfunction induced by similar mechanisms. Kinases involved in insulin- and cytokine-receptor signalling represent potential targets for innovative topical antipsoriatic therapies. |
| Databáze: | OpenAIRE |
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