| Předmět: |
0301 basic medicine
Neurogenesis Morphogenesis Cell migration Biology General Biochemistry Genetics and Molecular Biology Cortex (botany) Interneuron migration Protein deglutamylation 03 medical and health sciences Corticogenesis 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Cerebral cortex medicine Neuroscience 030217 neurology & neurosurgery |
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| Zdroj: | Cell. |
| ISSN: | 0092-8674 |
| Popis: | Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers. |
| Databáze: | OpenAIRE |
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