The effect of recrystallization on the crystal growth, melting point and solubility of ketoconazole
| Autor: | I.C.Rodriguez Galan, A. Cerezo Galan, I. Ismail Salem, César Viseras, A. Lopez Galindo |
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| Rok vydání: | 1995 |
| Předmět: |
Chromatography
Chemistry Recrystallization (metallurgy) Infrared spectroscopy Crystal growth Condensed Matter Physics Dosage form Transplantation Differential scanning calorimetry Melting point sense organs Physical and Theoretical Chemistry Solubility skin and connective tissue diseases Instrumentation Nuclear chemistry |
| Zdroj: | Thermochimica Acta. 268:143-151 |
| ISSN: | 0040-6031 |
| DOI: | 10.1016/0040-6031(95)02319-4 |
| Popis: | Variations in the physico-chemical properties of ketoconazole have been studied, following polymorphic changes caused by fusion-cooling processes or by recrystallization in solvents commonly used in the pharmaceutical industry. Changes in physico-chemical properties were measured by differential scanning calorimetry (DSC), infra-red, X-rays and HPLC. Results revealed changes in the peak temperature of the different recrystallizations and changes in their X-ray diffraction patterns. Infrared spectra of the samples indicated no changes in the chemical structure of ketoconazole. HPLC results indicated a decrease in the solubility except in one case. No degradation products were detected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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