| Autor: |
Theodore Ehrenreich, Werner Oppermann, Rafael A. Camerini-Davalos, Dhanoo Patel, Tanya Espinoza |
| Rok vydání: |
1973 |
| Předmět: |
|
| DOI: |
10.1016/b978-0-12-027362-1.50035-2 |
| Popis: |
Publisher Summary This chapter discusses certain findings based on studies of 130 KK and 64 S1 mice equally distributed according to age and sex. To identify the glomerular lesions more precisely, a temporary histological working classification was employed. The chapter illustrates an incidence of significant glomerular lesions among KK and control mice of both sexes. The diabetic syndrome in KK mice is not only associated with a higher incidence of glomerulosclerosis at an early age but it also accelerates the development of kidney pathology. There is no correlation between the degree of impairment in tolerance to glucose and the incidence of severe glomerulopathy when the glucose area levels throughout life are employed for evaluation of the degree of glucose dysmetabolism in KK mice. Correlative studies of severe glomerulopathy and degree of intolerance to glucose, based on 2 SD, gave similar negative results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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