Acute Leukemia of Myeloid, Lymphoid, and Ambiguous Lineage and Related Malignancies

Autor: Christine Beham-Schmid, Annette Schmitt-Graeff
Rok vydání: 2020
Předmět:
Zdroj: Essentials of Diagnostic Pathology ISBN: 9783662603079
Popis: The descriptive term “Leukamie/leukemia” was introduced by Rudolf Virchow who noticed the “white” color of blood samples obtained from patients presenting with high peripheral white blood cell counts and a reversed white and red blood cell balance [1]. The designation “acute leukemia” (AL) is actually applied to a heterogeneous group of immature clonal hematopoietic neoplasms occurring in all age groups. The large majority of AL is derived from either the myeloid or the lymphoid lineage, allowing a definite classification as acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL). The rare category “AL of ambiguous lineage” includes AL with no lineage-specific features and AL of mixed lymphoid/myeloid phenotype (MPAL) [2, 3].
Databáze: OpenAIRE