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Chemical investigation of anti-microbial and anti-fungal components of the leaves of Struchium sparganophora through the application of vacuum liquid chromatogtaphy (VLC), column liquid chromatography (CLC) and preparative thin layer chromatography (PTLC) resulted in isolation of a sesquiterpene lactone, vernodalinol. This compound was subjected to anti-fungal and cytotoxic tests. It exhibited a significant antifungal properties (P>.05) at the concentrations of 12.5 to 25 µg/ml and cytotoxic effects against melanoma and ovarian cancer cell lines at the concentrations of 3 - 5 x 10−3 µg/ml; the structure of this compound was determined by spectroscopic methods. This compound portend a useful chemotherapeutic agent in the treatment of fungal and cancer infections Key words: Struchium sparganophora. Asteraceae, elemanolide lactone, vernodalinol. |
