Viral Etiologies of Infant Bronchiolitis, Croup and Upper Respiratory Illness During 4 Consecutive Years
| Autor: | Kecia N. Carroll, Luke Heil, Zhouwen Liu, William D. Dupont, Kimberly B. Woodward, Laura Lee Morin, John V. Williams, E. Kathryn Miller, Tina V. Hartert, Yassir Mohamed, Patricia A. Minton, Tebeb Gebretsadik |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Pediatrics medicine.medical_specialty Respiratory tract infections business.industry viruses virus diseases medicine.disease_cause medicine.disease Infectious Diseases Bronchiolitis Croup Pediatrics Perinatology and Child Health Severity of illness Etiology Medicine business Prospective cohort study Coronavirus Cohort study |
| Zdroj: | Pediatric Infectious Disease Journal. 32:950-955 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0b013e31829b7e43 |
| Popis: | Background—Prospective data on viral etiology and clinical characteristics of bronchiolitis and upper respiratory illness in infants is limited. Methods—This prospective cohort enrolled previously healthy term infants during inpatient or outpatient visits for acute upper respiratory illness (URI) or bronchiolitis during September - May 2004–2008. Illness severity was determined using an ordinal bronchiolitis severity score. Common respiratory viruses were identified by real-time RT-PCR. Results—Of 648 infants, 67% were enrolled during inpatient visits and 33% during outpatient visits. Seventy percent had bronchiolitis, 3% croup, and 27% URI. Among infants with bronchiolitis, 76% had RSV, 18% HRV, 10% influenza, 2% coronavirus, 3% HMPV, and 1% PIV. Among infants with croup, 39% had HRV, 28% PIV, 28% RSV, 11% influenza, 6% coronavirus, and none HMPV. Among infants with URI, 46% had HRV, 14% RSV, 12% influenza, 7% coronavirus, 6% PIV, and 4% HMPV. Individual viruses exhibited distinct seasonal, demographic, and clinical expression. Conclusions—The most common infections among infants seeking care in unscheduled medical visits for URI or bronchiolitis were RSV and HRV. Demographic differences were observed between patients with different viruses, suggesting that host and viral factors play a role in phenotypic expression of viral illness. |
| Databáze: | OpenAIRE |
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